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Article

Impacts of cytoplasmic p53 aggregates on the prognosis and the transcriptome in lung squamous cell carcinoma.

Cancer science - 1 Sept 2024

Nishitsuji Kazuchika, Mito Remi, Ikezaki Midori, Yano Hiromu, Fujiwara Yukio, Matsubara Eri, Nishikawa Taro, Ihara Yoshito, Uchimura Kenji, Iwahashi Naoyuki, Sakagami Takuro, Suzuki Makoto, Komohara Yoshihiro

Abstract excerpt

The tumor suppressor TP53 gene, the most frequently mutated gene in human cancers, produces the product tumor protein p53, which plays an essential role in DNA damage. p53 protein mutations may contribute to tumorigenesis by loss of tumor suppressive functions and malignancy of cancer cells via gain-of-oncogenic functions. We previously reported that mutant p53 proteins form aggregates and that cytoplasmic p53...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

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Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

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Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 39031627
DOI: 10.1111/cas.16252
PMCID: PMC11462941

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