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Article

Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis

1 Jul 2022

Abstract excerpt

Abstract Recent studies suggested that aggregates of mutant p53 proteins may propagate and impair normal p53 functioning in recipient cells. Our previous study showed that cancer cell-derived p53 aggregates that cells internalized interfered with p53-dependent apoptosis in recipient cells. However, involvement of p53 aggregate propagation in cancer pathology has not been fully elucidated. Here, we screened...

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PMID: 36741442
DOI: 10.1093/pnasnexus/pgac128

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