Article
Δ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer.
British journal of cancer - 8 Nov 2011
Hofstetter G, Berger A, Schuster E, Wolf A, Hager G, Vergote I, Cadron I, Sehouli J, Braicu E I, Mahner S, Speiser P, Marth C, Zeimet A G, Ulmer H, Zeillinger R, Concin N
Abstract excerpt
BACKGROUND: We aimed to evaluate the clinical relevance of p53 and p73 isoforms that modulate the function of p53. METHODS: This prospective multicentre study included 154 patients with stage III and IV serous ovarian cancer. A functional yeast-based assay and subsequent sequencing were performed to analyse the p53 mutational status. Expression of p53 and p73 isoforms was determined using RT-qPCR. RESULTS:...
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