Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 protein aggregation promotes platinum resistance in ovarian cancer.

Oncogene - 1 Jul 2015

Yang-Hartwich Y, Soteras M G, Lin Z P, Holmberg J, Sumi N, Craveiro V, Liang M, Romanoff E, Bingham J, Garofalo F, Alvero A, Mor G

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC), the most lethal gynecological cancer, often leads to chemoresistant diseases. The p53 protein is a key transcriptional factor regulating cellular homeostasis. A majority of HGSOCs have inactive p53 because of genetic mutations. However, genetic mutation is not the only cause of p53 inactivation. The aggregation of p53 protein has been discovered in different types of...

Topics

Join the communities discussing this publication.

Carboplatin
Drug Resistance, Neoplasm
Mice, Nude
Ovarian Neoplasms
Platinum Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Aggregates

Protein Aggregation, Pathological

Tumor Cells, Cultured

Source

Identifiers

PMID: 25263447
DOI: 10.1038/onc.2014.296

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 protein aggregation promotes platinum resistance in ovarian cancer.PMID 25263447Read ↗

Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosisSemantic proximity Read ↗

Anticancer Therapeutic Strategies Targeting p53 Aggregation.Semantic proximity Read ↗

Gain-of-function p53 R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinomaSemantic proximity Read ↗

Association Between TP53 Mutations and Platinum Resistance in a Cohort of High-Grade Serous Ovarian Cancer Patients: Novel Implications for Personalized TherapeuticsSemantic proximity Read ↗

Impacts of cytoplasmic p53 aggregates on the prognosis and the transcriptome in lung squamous cell carcinoma.Semantic proximity Read ↗

Role of p53 isoforms and aggregations in cancerSemantic proximity Read ↗

ABCB1 confers resistance to carboplatin by accumulating stem-like cells in the G2/M phase of the cell cycle in p53null ovarian cancerSemantic proximity Read ↗

Establishment and characterization of a platinum- and paclitaxel-resistant high grade serous ovarian carcinoma cell line.Semantic proximity Read ↗

Establishment of Novel High-Grade Serous Ovarian Carcinoma Cell Line OVAR79.Semantic proximity Read ↗

Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression.Semantic proximity Read ↗

Mutated p53 in HGSC—From a Common Mutation to a Target for TherapySemantic proximity Read ↗

Amyloid-like p53 as prognostic biomarker in serous ovarian cancer-a study of the OVCAD consortium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.