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Article

Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability.

American journal of human genetics - 6 Jul 2023

Wang Xiaotong, Walker Alicia, Revez Joana A, Ni Guiyan, Adams Mark J, McIntosh Andrew M, Visscher Peter M, Wray Naomi R

Abstract excerpt

In polygenic score (PGS) analysis, the coefficient of determination (R2) is a key statistic to evaluate efficacy. R2 is the proportion of phenotypic variance explained by the PGS, calculated in a cohort that is independent of the genome-wide association study (GWAS) that provided estimates of allelic effect sizes. The SNP-based heritability (hSNP2, the proportion of total phenotypic variances attributable to all...

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PMID: 37379836
DOI: 10.1016/j.ajhg.2023.06.006
PMCID: PMC10357496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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