Interpreting SNP heritability in admixed populations.

Abstract excerpt

Single-nucleotide polymorphism (SNP) heritability (hsnp2) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of heritability (h2), being equal to it if all causal variants are genotyped. Despite the simple intuition behind hsnp2, its interpretation and equivalence to h2 is unclear, particularly in the presence of admixture and assortative mating....

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