Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification.

Nature genetics - 1 Jan 2022

Ding Yi, Hou Kangcheng, Burch Kathryn S, Lapinska Sandra, Privé Florian, Vilhjálmsson Bjarni, Sankararaman Sriram, Pasaniuc Bogdan

Abstract excerpt

Although the cohort-level accuracy of polygenic risk scores (PRSs)-estimates of genetic value at the individual level-has been widely assessed, uncertainty in PRSs remains underexplored. In the present study, we show that Bayesian PRS methods can estimate the variance of an individual's PRS and can yield well-calibrated credible intervals via posterior sampling. For 13 real traits in the UK Biobank (n = 291,273...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Models, Genetic

Share to Models, Statistical

Share to Multifactorial Inheritance

Share to Risk Assessment

Share to Uncertainty

Source

Open in PubMed Open full text

Identifiers

PMID: 34931067
DOI: 10.1038/s41588-021-00961-5
PMCID: PMC8758557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification.PMID 34931067Read ↗

iPRSue: Unbiased individual-level uncertainty estimation in polygenic risk scoresSemantic proximity Read ↗

A guide to performing Polygenic Risk Score analysesSemantic proximity Read ↗

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives.Semantic proximity Read ↗

Significant Sparse Polygenic Risk Scores across 813 traits in UK BiobankSemantic proximity Read ↗

The emerging field of polygenic risk scores and perspective for use in clinical care.Semantic proximity Read ↗

Polygenic Risk Scores in Human Disease.Semantic proximity Read ↗

Polygenic risk score prediction accuracy convergenceSemantic proximity Read ↗

Positioning Personal Polygenic Risk score against the population backgroundSemantic proximity Read ↗

Advancements and limitations in polygenic risk score methods for genomic prediction: a scoping review.Semantic proximity Read ↗

Significant sparse polygenic risk scores across 813 traits in UK Biobank.Semantic proximity Read ↗

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for EpidemiologistsSemantic proximity Read ↗

Admixture-informed polygenic risk reporting using the ePRS framework.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.