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Deoptimization of FMDV P1 Region Results in Robust Serotype-Independent Viral Attenuation

6 Jun 2023

Abstract excerpt

Foot-and-mouth disease (FMD), caused by the FMD virus (FMDV), is a highly contagious disease of cloven-hoofed livestock that can have severe economic impacts. Control and prevention strategies, including the development of improved vaccines, are urgently needed to effectively control FMD outbreaks in endemic settings. Previously, we employed two distinct strategies (codon pair bias deoptimization (CPD) and codon...

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PMID: 37376631
DOI: 10.3390/v15061332

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