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Article

Application of codon pair deoptimization for ORF7-induced attenuation of type I porcine reproductive and respiratory syndrome virus without reduced immune responses.

Virology - 1 Feb 2023

Cha Sang-Ho, You Su-Hwa, Lee Min-A, Baek Jong-Hyuk, Cho Sun-Hee, Jeong Jiwoon, Park Chang-Joo, Lee Myung-Shin, Park Changhoon

Abstract excerpt

Codon pair deoptimization (CPD) attenuated type I porcine reproductive and respiratory syndrome virus (PRRSV). Infectious clones covering the full genome of a Korean type I PRRSV (E38) were synthesized, and CPD induced nine synonymous mutants of NSP1 (n = 1) and ORF7 (n = 8). In a trial to rescue live viruses from infectious clones, only four clones with mutations at nt 177 downstream of ORF7 were rescued, which...

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PMID: 36669328
DOI: 10.1016/j.virol.2023.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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