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Article

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2017

Le Nouën Cyril, McCarty Thomas, Brown Michael, Smith Melissa Laird, Lleras Roberto, Dolan Michael A, Mehedi Masfique, Yang Lijuan, Luongo Cindy, Liang Bo, Munir Shirin, DiNapoli Joshua M, Mueller Steffen, Wimmer Eckard, Collins Peter L, Buchholz Ursula J

Abstract excerpt

Recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. These vaccine candidates should have a low risk of deattenuation because of the many changes involved. However, their genetic stability under selective pressure is largely unknown. We evaluated phenotypic reversion of deoptimized human respiratory syncytial virus (RSV) vaccine candidates in the...

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PMID: 28049853
DOI: 10.1073/pnas.1619242114
PMCID: PMC5255620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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