Article

Vaccinia virus attenuation by codon deoptimization of the A24R gene for vaccine development

2022-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Poxviruses have large DNA genomes and they are able to infect multiple vertebrate and invertebrate animals, including humans. Despite the eradication of smallpox, poxvirus infections still remain a significant public health concern. Vaccinia virus (VV) is the prototypic member in the poxviridae family and it has been used extensively for different therapeutic applications, including the generat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd013928-720e-524d-bb8b-1ccb05f22edf
DOI: 10.1101/2022.01.23.477337

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vaccinia virus attenuation by codon deoptimization of the A24R gene for vaccine developmentDOI 10.1101/2022.01.23.477337Read

Downregulating Viral Gene Expression: Codon Usage Bias Manipulation for the Generation of Novel Influenza A Virus VaccinesSemantic proximity Read

Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimizationSemantic proximity Read

Influenza A Virus Attenuation by Codon Deoptimization of the NS Gene for Vaccine DevelopmentSemantic proximity Read

Tools for the targeted genetic modification of poxvirus genomes.Semantic proximity Read

Optimization and deoptimization of codons in SARS-CoV-2 and the implications for vaccine developmentSemantic proximity Read

The Evolution of Poxvirus VaccinesSemantic proximity Read

Genome-Scale Codon Deoptimization Enables Attenuation of Rift Valley Fever VirusSemantic proximity Read

A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primatesSemantic proximity Read

Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence GenesSemantic proximity Read

Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoesSemantic proximity Read

Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine CandidateSemantic proximity Read

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimizationSemantic proximity Read