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Article

Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity.

Journal of virology - 1 Oct 2006

Mueller Steffen, Papamichail Dimitris, Coleman J Robert, Skiena Steven, Wimmer Eckard

Abstract excerpt

Exploring the utility of de novo gene synthesis with the aim of designing stably attenuated polioviruses (PV), we followed two strategies to construct PV variants containing synthetic replacements of the capsid coding sequences either by deoptimizing synonymous codon usage (PV-AB) or by maximizing synonymous codon position changes of the existing wild-type (wt) poliovirus codons (PV-SD). Despite 934 nucleotide...

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Identifiers

PMID: 16973573
DOI: 10.1128/JVI.00738-06
PMCID: PMC1617239

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