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Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

29 Jan 2018

Abstract excerpt

Codon pair bias deoptimization (CPBD) has enabled highly efficient and rapid attenuation of RNA viruses. The technique relies on recoding of viral genes by increasing the number of codon pairs that are statistically underrepresented in protein coding genes of the viral host without changing the amino acid sequence of the encoded proteins. Utilization of naturally underrepresented codon pairs reduces protein...

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PMID: 29377958
DOI: 10.1371/journal.ppat.1006857

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