Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models

20 Jun 2018

Abstract excerpt

Due to unprecedented epidemics of Zika virus (ZIKV) across the Americas and the unexpected clinical symptoms, including Guillain-Barré syndrome, microcephaly, and other birth defects in humans, there is an urgent need for ZIKV vaccine development. Here we provided the first attenuated versions of ZIKV with two important genes (E and/or NS1) that were subjected to codon pair deoptimization. Compared to parental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29925661
DOI: 10.1128/jvi.00701-18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse ModelsPMID 29925661Read ↗

Virus attenuation by genome-scale changes in codon pair bias.Semantic proximity Read ↗

A single nonsynonymous mutation on gene encoding E protein of Zika virus leads to increased neurovirulence <i>in vivo</i>Semantic proximity Read ↗

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimizationSemantic proximity Read ↗

A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host.Semantic proximity Read ↗

An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.Semantic proximity Read ↗

Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell cultureSemantic proximity Read ↗

Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoesSemantic proximity Read ↗

A single nonsynonymous mutation on ZIKV E protein-coding sequences leads to markedly increased neurovirulence in vivo.Semantic proximity Read ↗

Evolution of codon usage in Zika virus genomes is host and vector specific.Semantic proximity Read ↗

A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primatesSemantic proximity Read ↗

Genome-Scale Codon Deoptimization Enables Attenuation of Rift Valley Fever VirusSemantic proximity Read ↗

Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.