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Article

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

25 Aug 2014

Abstract excerpt

Human respiratory syncytial virus (RSV) is the most important viral agent of serious pediatric respiratory-tract disease worldwide. A vaccine or generally effective antiviral drug is not yet available. We designed new live attenuated RSV vaccine candidates by codon-pair deoptimization (CPD). Specifically, viral ORFs were recoded by rearranging existing synonymous codons to increase the content of underrepresented...

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PMID: 25157129
DOI: 10.1073/pnas.1411290111

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