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Adaptive Evolution of Serotype O Foot-and-Mouth Disease Virus Under Vaccine Pressure: Combined VP1 T142/Q153 Mutations Drive Antigenic Alteration and Immune Evasion.

Transboundary and emerging diseases - 1 Jan 2026

Cao Nan, Li Yamei, Chen Xinghua, Zhao Qiongqiong, Zhang Jinyan, Shang Xianfei, Hou Junling, Zhang Jinming, Yin Bo, Wu Jinyan, Li Xiangmin, Qian Ping

Abstract excerpt

Foot-and-mouth disease virus (FMDV) escapes host immune surveillance via adaptive evolution driven by vaccine-mediated selective pressure, leading to persistent breakthrough infections in immunized animals. In this study, the dominant neutralizing epitope VP1 G-H loop (141-160 aa) was analyzed among 46 serotype O FMDV strains belonging to Southeast Asian (SEA) and Middle East-South Asian (ME-SA) topotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42438383
DOI: 10.1155/tbed/4808637
PMCID: PMC13358367

Genes

SEA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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