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Article

Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis.

Leukemia - 1 Feb 2022

Shinoda Daisuke, Nakajima-Takagi Yaeko, Oshima Motohiko, Koide Shuhei, Aoyama Kazumasa, Saraya Atsunori, Harada Hironori, Rahmutulla Bahityar, Kaneda Atsushi, Yamaguchi Kiyoshi, Furukawa Yoichi, Koseki Haruhiko, Shimoda Kazuya, Tanaka Tomoaki, Sashida Goro, Iwama Atsushi

Abstract excerpt

Insufficiency of polycomb repressive complex 2 (PRC2), which trimethylates histone H3 at lysine 27, is frequently found in primary myelofibrosis and promotes the development of JAK2V617F-induced myelofibrosis in mice by enhancing the production of dysplastic megakaryocytes. Polycomb group ring finger protein 1 (Pcgf1) is a component of PRC1.1, a non-canonical PRC1 that monoubiquitylates H2A at lysine 119...

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PMID: 34497325
DOI: 10.1038/s41375-021-01402-2

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Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis.PMID 34497325Read ↗

[Pathogenic role of insufficiency of polycomb repressive complex in primary myelofibrosis].Semantic proximity Read ↗

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibitionSemantic proximity Read ↗

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The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemiaSemantic proximity Read ↗

Polycomb complexes in normal and malignant hematopoiesisSemantic proximity Read ↗

Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasmsSemantic proximity Read ↗

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Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent mannerSemantic proximity Read ↗

Clarifying the Impact of Polycomb Complex Component Disruption in Human CancersSemantic proximity Read ↗

Loss of <i>Ezh2</i> synergizes with <i>JAK2</i> -V617F in initiating myeloproliferative neoplasms and promoting myelofibrosisSemantic proximity Read ↗

PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome.Semantic proximity Read ↗

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