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Article

TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues.

Development (Cambridge, England) - 1 Dec 2011

Shibata Maho, Blauvelt Kristin E, Liem Karel F, García-García María J

Abstract excerpt

TRIM28 is a transcriptional regulator that is essential for embryonic development and is implicated in a variety of human diseases. The roles of TRIM28 in distinct biological processes are thought to depend on its interaction with factors that determine its DNA target specificity. However, functional evidence linking TRIM28 to specific co-factors is scarce. chatwo, a hypomorphic allele of Trim28, causes embryonic...

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Identifiers

PMID: 22110054
DOI: 10.1242/dev.072546
PMCID: PMC3222210

Genes

TRIM28

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues.PMID 22110054Read ↗

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Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.Semantic proximity Read ↗

Trim28 is required for epigenetic stability during mouse oocyte to embryo transition.Semantic proximity Read ↗

Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain.Semantic proximity Read ↗

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