Base editing reveals context-dependent regulation of adhesion, anoikis, and motility by BAP1 in renal cell models.

Abstract excerpt

BAP1 is a tumor-suppressive deubiquitinase essential for DNA repair, and missense mutations in BAP1 are common in clear cell renal cell carcinoma (ccRCC). We previously showed that correction of the inactivating Glu31Lys mutation in KMRC-20 ccRCC cells using CRISPR/Cas9 base editing restored BAP1 function, reinstated anchorage dependence, and re-sensitized cells to anoikis. Here, we investigated whether...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carcinoma, Renal Cell
• Share to Cell Adhesion