Article
Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations.
Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007
Gao ChongFeng, Furge Kyle, Koeman Julie, Dykema Karl, Su Yanli, Cutler Mary Lou, Werts Adam, Haak Pete, Vande Woude George F
Abstract excerpt
Chromosome instability and aneuploidy are hallmarks of cancer, but it is not clear how changes in the chromosomal content of a cell contribute to the malignant phenotype. Previously we have shown that we can readily isolate highly proliferative tumor cells and their revertants from highly invasiv...
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