Article

Base Editing Reveals Context-Dependent Regulation of Adhesion, Anoikis, and Motility by BAP1 in Renal Cell Models

2026-01-09

Abstract excerpt

<title>Abstract</title> <p>Background BAP1 is a tumor-suppressive deubiquitinase essential for DNA repair, and missense mutations in BAP1 are common in clear cell renal cell carcinoma (ccRCC). We previously showed that precise correction of the inactivating Glu31Lys mutation in KMRC-20 ccRCC cells using CRISPR/Cas9 base editing restored BAP1 activity, reinstated anchorage-dependent growth, and re-sensitized cell...

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Literature Corpus work: 8ca4b0e6-1fbb-5395-9c63-1c4a57dc52e1
DOI: 10.21203/rs.3.rs-8306241/v1

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