Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome instability drives phenotypic switching to metastasis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016

Gao ChongFeng, Su Yanli, Koeman Julie, Haak Elizabeth, Dykema Karl, Essenberg Curt, Hudson Eric, Petillo David, Khoo Sok Kean, Vande Woude George F

Abstract excerpt

Chromosome instability (CIN) is the most striking feature of human cancers. However, how CIN drives tumor progression to metastasis remains elusive. Here we studied the role of chromosome content changes in generating the phenotypic dynamics that are required for metastasis. We isolated epithelial and mesenchymal clones from human carcinoma cell lines and showed that the epithelial clones were able to generate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Cells
Share to Aneuploidy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

Share to Epithelial-Mesenchymal Transition

Share to Epithelium

Share to Karyotyping

Share to Mesoderm

Share to Neoplasm Metastasis

Source

Open in PubMed Open full text

Identifiers

PMID: 27930335
DOI: 10.1073/pnas.1618215113
PMCID: PMC5187712

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome instability drives phenotypic switching to metastasis.PMID 27930335Read ↗

Epithelial-to-mesenchymal transition drives cancer genomic instabilitySemantic proximity Read ↗

Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations.Semantic proximity Read ↗

Mutational drivers of cancer cell migration and invasion.Semantic proximity Read ↗

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancerSemantic proximity Read ↗

Metastasis as an evolutionary process.Semantic proximity Read ↗

9p21 Loss Defines the Evolutionary Patterns of Aggressive Renal Cell CarcinomasSemantic proximity Read ↗

Epithelial-Mesenchymal Transitions in Cancer ProgressionSemantic proximity Read ↗

Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor MetastasisSemantic proximity Read ↗

Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancerSemantic proximity Read ↗

Molecular cytogenetic analysis of a human breast metastasis model: identification of phenotype-specific chromosomal rearrangements.Semantic proximity Read ↗

A Model for the Diversity Explosion Fundamental to MetastasisSemantic proximity Read ↗

Paradoxical relationship between chromosomal instability and survival outcome in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.