Article
Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2023
Lai John, Wong Chi Kuen, Schmidt Daniel F, Kapuscinski Miroslaw K, Alpen Karen, MacInnis Robert J, Buchanan Daniel D, Win Aung K, Figueiredo Jane C, Chan Andrew T, Harrison Tabitha A, Hoffmeister Michael, White Emily, Le Marchand Loic, Pai Rish K, Peters Ulrike, Hopper John L, Jenkins Mark A, Makalic Enes
Abstract excerpt
BACKGROUND: DEPendency of association on the number of Top Hits (DEPTH) is an approach to identify candidate susceptibility regions by considering the risk signals from overlapping groups of sequential variants across the genome. METHODS: We applied a DEPTH analysis using a sliding window of 200 SNPs to colorectal cancer data from the Colon Cancer Family Registry (CCFR; 5,735 cases and 3,688 controls), and...
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