Article
Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.
American journal of human genetics - 3 Sept 2020
Thomas Minta, Sakoda Lori C, Hoffmeister Michael, Rosenthal Elisabeth A, Lee Jeffrey K, van Duijnhoven Franzel J B, Platz Elizabeth A, Wu Anna H, Dampier Christopher H, de la Chapelle Albert, Wolk Alicja, Joshi Amit D, Burnett-Hartman Andrea, Gsur Andrea, Lindblom Annika, Castells Antoni, Win Aung Ko, Namjou Bahram, Van Guelpen Bethany, Tangen Catherine M, He Qianchuan, Li Christopher I, Schafmayer Clemens, Joshu Corinne E, Ulrich Cornelia M, Bishop D Timothy, Buchanan Daniel D, Schaid Daniel, Drew David A, Muller David C, Duggan David, Crosslin David R, Albanes Demetrius, Giovannucci Edward L, Larson Eric, Qu Flora, Mentch Frank, Giles Graham G, Hakonarson Hakon, Hampel Heather, Stanaway Ian B, Figueiredo Jane C, Huyghe Jeroen R, Minnier Jessica, Chang-Claude Jenny, Hampe Jochen, Harley John B, Visvanathan Kala, Curtis Keith R, Offit Kenneth, Li Li, Le Marchand Loic, Vodickova Ludmila, Gunter Marc J, Jenkins Mark A, Slattery Martha L, Lemire Mathieu, Woods Michael O, Song Mingyang, Murphy Neil, Lindor Noralane M, Dikilitas Ozan, Pharoah Paul D P, Campbell Peter T, Newcomb Polly A, Milne Roger L, MacInnis Robert J, Castellví-Bel Sergi, Ogino Shuji, Berndt Sonja I, Bézieau Stéphane, Thibodeau Stephen N, Gallinger Steven J, Zaidi Syed H, Harrison Tabitha A, Keku Temitope O, Hudson Thomas J, Vymetalkova Veronika, Moreno Victor, Martín Vicente, Arndt Volker, Wei Wei-Qi, Chung Wendy, Su Yu-Ru, Hayes Richard B, White Emily, Vodicka Pavel, Casey Graham, Gruber Stephen B, Schoen Robert E, Chan Andrew T, Potter John D, Brenner Hermann, Jarvik Gail P, Corley Douglas A, Peters Ulrike, Hsu Li
Abstract excerpt
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at low and high risk of developing CRC, as they can then be offered targeted screening and interventions to address their risks of developing disease (if they are in a high-risk group) and avoid unnecessary screening and interventions (if they are in a low-risk group). As it is likely that thousands of genetic...
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