Article
Evaluating the predictive value of genetic risk score in colorectal cancer among Chinese Han population.
Journal of human genetics - 1 Mar 2020
Ye Ding, Jiang Danjie, Gu Simeng, Mao Yingying, Qian Sangni, Lin Shujuan, Li Qilong, Yang Jinhua, Zhong Kunhong, Jin Mingjuan, Chen Kun
Abstract excerpt
Increasing single nucleotide polymorphisms (SNPs) have been identified to be associated with colorectal cancer (CRC). We aimed to investigate whether genetic risk scores (GRS) that aggregate information from multiple genetic variants can predict the risk of CRC in a Chinese population. Fifty candidate SNPs were selected to explore the associations with CRC in a discovery sample with 1002 CRC cases and 999 healthy...
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