Article
Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans.
Human molecular genetics - 15 Dec 2013
Wang Hansong, Haiman Christopher A, Burnett Terrilea, Fortini Barbara K, Kolonel Laurence N, Henderson Brian E, Signorello Lisa B, Blot William J, Keku Temitope O, Berndt Sonja I, Newcomb Polly A, Pande Mala, Amos Christopher I, West Dee W, Casey Graham, Sandler Robert S, Haile Robert, Stram Daniel O, Le Marchand Loïc
Abstract excerpt
Genome-wide association studies of colorectal cancer (CRC) in Europeans and Asians have identified 21 risk susceptibility regions [29 index single-nucleotide polymorphisms (SNPs)]. Characterizing these risk regions in diverse racial groups with different linkage disequilibrium (LD) structure can help localize causal variants. We examined associations between CRC and all 29 index SNPs in 6597 African Americans...
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