Article
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Nature communications - 7 Jul 2015
Schumacher Fredrick R, Schmit Stephanie L, Jiao Shuo, Edlund Christopher K, Wang Hansong, Zhang Ben, Hsu Li, Huang Shu-Chen, Fischer Christopher P, Harju John F, Idos Gregory E, Lejbkowicz Flavio, Manion Frank J, McDonnell Kevin, McNeil Caroline E, Melas Marilena, Rennert Hedy S, Shi Wei, Thomas Duncan C, Van Den Berg David J, Hutter Carolyn M, Aragaki Aaron K, Butterbach Katja, Caan Bette J, Carlson Christopher S, Chanock Stephen J, Curtis Keith R, Fuchs Charles S, Gala Manish, Giovannucci Edward L, Gogarten Stephanie M, Hayes Richard B, Henderson Brian, Hunter David J, Jackson Rebecca D, Kolonel Laurence N, Kooperberg Charles, Küry Sébastien, LaCroix Andrea, Laurie Cathy C, Laurie Cecelia A, Lemire Mathieu, Levine David, Ma Jing, Makar Karen W, Qu Conghui, Taverna Darin, Ulrich Cornelia M, Wu Kana, Kono Suminori, West Dee W, Berndt Sonja I, Bezieau Stéphane, Brenner Hermann, Campbell Peter T, Chan Andrew T, Chang-Claude Jenny, Coetzee Gerhard A, Conti David V, Duggan David, Figueiredo Jane C, Fortini Barbara K, Gallinger Steven J, Gauderman W James, Giles Graham, Green Roger, Haile Robert, Harrison Tabitha A, Hoffmeister Michael, Hopper John L, Hudson Thomas J, Jacobs Eric, Iwasaki Motoki, Jee Sun Ha, Jenkins Mark, Jia Wei-Hua, Joshi Amit, Li Li, Lindor Noralene M, Matsuo Keitaro, Moreno Victor, Mukherjee Bhramar, Newcomb Polly A, Potter John D, Raskin Leon, Rennert Gad, Rosse Stephanie, Severi Gianluca, Schoen Robert E, Seminara Daniela, Shu Xiao-Ou, Slattery Martha L, Tsugane Shoichiro, White Emily, Xiang Yong-Bing, Zanke Brent W, Zheng Wei, Le Marchand Loic, Casey Graham, Gruber Stephen B, Peters Ulrike
Abstract excerpt
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new...
