Article
Genome-wide search for gene-gene interactions in colorectal cancer.
PloS one - 1 Jan 2012
Jiao Shuo, Hsu Li, Berndt Sonja, Bézieau Stéphane, Brenner Hermann, Buchanan Daniel, Caan Bette J, Campbell Peter T, Carlson Christopher S, Casey Graham, Chan Andrew T, Chang-Claude Jenny, Chanock Stephen, Conti David V, Curtis Keith R, Duggan David, Gallinger Steven, Gruber Stephen B, Harrison Tabitha A, Hayes Richard B, Henderson Brian E, Hoffmeister Michael, Hopper John L, Hudson Thomas J, Hutter Carolyn M, Jackson Rebecca D, Jenkins Mark A, Kantor Elizabeth D, Kolonel Laurence N, Küry Sébastien, Le Marchand Loic, Lemire Mathieu, Newcomb Polly A, Potter John D, Qu Conghui, Rosse Stephanie A, Schoen Robert E, Schumacher Fred R, Seminara Daniela, Slattery Martha L, Ulrich Cornelia M, Zanke Brent W, Peters Ulrike
Abstract excerpt
Genome-wide association studies (GWAS) have successfully identified a number of single-nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk. However, these susceptibility loci known today explain only a small fraction of the genetic risk. Gene-gene interaction (GxG) is considered to be one source of the missing heritability. To address this, we performed a genome-wide search for pair-wise...
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