Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.

doi:10.1371/journal.pone.0157521

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Article

Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.

PloS one - 1 Jan 2016

Du Mengmeng, Jiao Shuo, Bien Stephanie A, Gala Manish, Abecasis Goncalo, Bezieau Stephane, Brenner Hermann, Butterbach Katja, Caan Bette J, Carlson Christopher S, Casey Graham, Chang-Claude Jenny, Conti David V, Curtis Keith R, Duggan David, Gallinger Steven, Haile Robert W, Harrison Tabitha A, Hayes Richard B, Hoffmeister Michael, Hopper John L, Hudson Thomas J, Jenkins Mark A, Küry Sébastien, Le Marchand Loic, Leal Suzanne M, Newcomb Polly A, Nickerson Deborah A, Potter John D, Schoen Robert E, Schumacher Fredrick R, Seminara Daniela, Slattery Martha L, Hsu Li, Chan Andrew T, White Emily, Berndt Sonja I, Peters Ulrike

Abstract excerpt

Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of functional candidates and additional independent risk variants. We analyzed 11,900 cases and 14,311 controls in the Genetics and Epidemiology of...

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PMID: 27379672
DOI: 10.1371/journal.pone.0157521
PMCID: PMC4933364

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