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Article

Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation.

Stem cell research - 1 Sept 2023

Sun Wenxian, Wang Pin, Gong Jin, Chen Yufei, Yang Yuting, Luan Heya, Li Shaoqi, Li Ruina, Wei Cuibai

Abstract excerpt

The β-amyloid precursor protein (APP) is a crucial pathogenic gene linked to Alzheimer's disease (AD). A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) isolated from a female with APP gene mutation utilizing non-integrative Sendai virus. The iPSC line exhibits high expression of pluripotency markers, retains the APP mutation, displays a normal...

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Identifiers

PMID: 37356183
DOI: 10.1016/j.scr.2023.103149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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