Article
Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease.
Stem cell research - 1 Oct 2020
Rolova Taisia, Wu Ying-Chieh, Koskuvi Marja, Voutilainen Jenni, Sonninen Tuuli-Maria, Kuusisto Johanna, Laakso Markku, Hämäläinen Riikka H, Koistinaho Jari, Lehtonen Šárka
Abstract excerpt
A673T mutation in the amyloid precursor protein (APP) is a rare variant associated with a reduced risk of late-onset Alzheimer's disease (AD) and age-related cognitive decline. The A673T mutation decreases beta-amyloid (Aβ) production and aggregation in neuronal cultures in vitro. Here we have identified a Finnish non-diseased male individual carrying a heterozygous A673T mutation, obtained a skin biopsy sample...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.