Article
Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene.
Stem cell research - 1 Aug 2018
Oksanen Minna, Hyötyläinen Ida, Voutilainen Jenni, Puttonen Katja A, Hämäläinen Riikka H, Graff Caroline, Lehtonen Šárka, Koistinaho Jari
Abstract excerpt
A double mutation (KM670/671NL) in amyloid precursor protein gene (APP) is causative for familial Alzheimer's disease and has been shown to increase the total Aβ burden. Here we report the generation and characterization of an iPSC line from a fAD patient carrying APP KM670/671NL. The generated iPSCs retained the mutation, expressed pluripotency markers, showed a normal karyotype and differentiated into all three...
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