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Article

Establishment of induced pluripotent stem cell line (ZZUi010-A) from an Alzheimer's disease patient carrying an APP gene mutation.

Stem cell research - 1 Dec 2017

Wang Zhilei, Zhang Pei, Wang Yanlin, Shi Changhe, Jing Na, Sun Huifang, Yang Jing, Liu Yutao, Wen Xuejun, Zhang Jin, Zhang Shoutao, Xu Yuming

Abstract excerpt

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders. Previous studies have identified mutations in several genes, such as amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2), in patients with early-onset (<65years) familial AD. Recently, a patient with an APP gene mutation was identified; the dermal fibroblasts of the patient were obtained and a line of...

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Source

Identifiers

PMID: 29156377
DOI: 10.1016/j.scr.2017.10.025

Genes

APP
PSEN1
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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