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Generation of induced pluripotent stem cell line (ZZUi0024-A) from a 51-year-old patient with APP gene mutation in Alzheimer' s disease.

Stem cell research - 1 May 2021

Wang Zhuoya, Sun Huifang, Zhang Qi, Yang Jing, Liu Yutao, Liu Han, Shi Changhe, Wang Yanlin, Xu Yuming

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disease that manifests mainly as cognitive, behavioral, and neuropsychiatric changes and impairs social functions and activities of daily living. The β-amyloid precursor protein (APP) gene is one of the most common pathogenic genes associated with AD. We isolated dermal fibroblasts from a 51-year-old woman with an APP gene mutation (c.1756G > A). The induced...

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PMID: 33652304
DOI: 10.1016/j.scr.2021.102267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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