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Article

Digest: Few new mutations are recessive lethal.

Evolution; international journal of organic evolution - 27 Jul 2023

Epley Benjamin R

Abstract excerpt

When a new mutation arises, what is the probability that it is recessive lethal? Wade et al. find that fewer than 1% of nonsynonymous mutations in humans and Drosophila melanogaster are recessive lethal. The authors show that methods based on site frequency spectrum (SFS) analyses, though generally robust in their estimations of the nonlethal distribution of fitness effects (DFE), are unable to accurately...

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Identifiers

PMID: 37354114
DOI: 10.1093/evolut/qpad117
PMCID: PMC10373208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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