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Article

Quantifying the fraction of new mutations that are recessive lethal.

Evolution; international journal of organic evolution - 29 Jun 2023

Wade Emma E, Kyriazis Christopher C, Cavassim Maria Izabel A, Lohmueller Kirk E

Abstract excerpt

The presence and impact of recessive lethal mutations have been widely documented in diploid outcrossing species. However, precise estimates of the proportion of new mutations that are recessive lethal remain limited. Here, we evaluate the performance of Fit∂a∂i, a commonly used method for inferring the distribution of fitness effects (DFE), in the presence of lethal mutations. Using simulations, we demonstrate...

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Identifiers

PMID: 37074880
DOI: 10.1093/evolut/qpad061
PMCID: PMC10309970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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