Article

Determining the factors driving selective effects of new nonsynonymous mutations

2016-08-23

Abstract excerpt

The distribution of fitness effects (DFE) of new mutations is a fundamental parameter in evolutionary genetics 1–3 . While theoretical models have emphasized the importance of distinct biological factors, such as protein folding 4 , back mutations 5 , species complexity 6,7 , and mutational robustness 8 at determining the DFE, it remains unclear which of these models can describe the DFE in natural population...

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Literature Corpus work: 9924cc0e-cb93-5313-9839-e32fc29d4775
DOI: 10.1101/071209

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