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Article

What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Apr 2010

Keightley Peter D, Eyre-Walker Adam

Abstract excerpt

We investigate several questions concerning the inference of the distribution of fitness effects (DFE) of new mutations from the distribution of nucleotide frequencies in a population sample. If a fixed sequencing effort is available, we find that the optimum strategy is to sequence a modest number of alleles (approx. 10). If full genome information is available, the accuracy of parameter estimates increases as...

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Identifiers

PMID: 20308093
DOI: 10.1098/rstb.2009.0266
PMCID: PMC2871813

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Source receipt: pubmed, retrieved 7 Sept 2026.

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