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Article

Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis.

Cell reports - 12 Jan 2021

Arber Charles, Lovejoy Christopher, Harris Lachlan, Willumsen Nanet, Alatza Argyro, Casey Jackie M, Lines Georgie, Kerins Caoimhe, Mueller Anika K, Zetterberg Henrik, Hardy John, Ryan Natalie S, Fox Nick C, Lashley Tammaryn, Wray Selina

Abstract excerpt

Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer's disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression data from developmental and adult neurogenesis show relative enrichment of Notch and γ-secretase expression in stem cells, whereas expression of APP and β-secretase is enriched in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33440141
DOI: 10.1016/j.celrep.2020.108615
PMCID: PMC7809623

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