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Article

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.

PloS one - 1 Jan 2014

Sproul Andrew A, Jacob Samson, Pre Deborah, Kim Soong Ho, Nestor Michael W, Navarro-Sobrino Miriam, Santa-Maria Ismael, Zimmer Matthew, Aubry Soline, Steele John W, Kahler David J, Dranovsky Alex, Arancio Ottavio, Crary John F, Gandy Sam, Noggle Scott A

Abstract excerpt

Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD). In order to elucidate pathways downstream of PSEN1, we characterized neural progenitor cells (NPCs) derived from FAD mutant PSEN1 subjects. Thus, we generated induced pluripotent stem cells (iPSCs) from affected and unaffected individuals from two...

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Identifiers

PMID: 24416243
DOI: 10.1371/journal.pone.0084547
PMCID: PMC3885572

Genes

PSEN1

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