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Modeling familial Alzheimer's disease with induced pluripotent stem cells.

Human molecular genetics - 1 Dec 2011

Yagi Takuya, Ito Daisuke, Okada Yohei, Akamatsu Wado, Nihei Yoshihiro, Yoshizaki Takahito, Yamanaka Shinya, Okano Hideyuki, Suzuki Norihiro

Abstract excerpt

Alzheimer's disease (AD) is the most common form of age-related dementia, characterized by progressive memory loss and cognitive disturbance. Mutations of presenilin 1 (PS1) and presenilin 2 (PS2) are causative factors for autosomal-dominant early-onset familial AD (FAD). Induced pluripotent stem cell (iPSC) technology can be used to model human disorders and provide novel opportunities to study cellular...

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PMID: 21900357
DOI: 10.1093/hmg/ddr394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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