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Cord blood–derived V δ 2 + and V δ 2 − T cells acquire differential cell state compositions upon in vitro expansion

16 Jun 2023

Abstract excerpt

Human cord blood–derived γδ T cells (CB γδ ) display a highly diverse TCR γδ repertoire and have a unique subtype composition different from fetal or adult peripheral blood counterparts. We expanded CB γδ in vitro using an irradiated Epstein-Barr virus–transformed feeder cell–based modified rapid expansion protocol (REP). Single-cell RNA sequencing tracked progressive differentiation of naïve CB γδ into cells...

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PMID: 37327346
DOI: 10.1126/sciadv.adf3120

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