Article
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes.
Blood - 27 Aug 2009
Hanley Patrick J, Cruz Conrad Russell Young, Savoldo Barbara, Leen Ann M, Stanojevic Maja, Khalil Mariam, Decker William, Molldrem Jeffrey J, Liu Hao, Gee Adrian P, Rooney Cliona M, Heslop Helen E, Dotti Gianpietro, Brenner Malcolm K, Shpall Elizabeth J, Bollard Catherine M
Abstract excerpt
The naive phenotype of cord blood (CB) T cells may reduce graft-versus-host disease after umbilical cord blood transplantation, but this naivety and their low absolute numbers also delays immune reconstitution, producing higher infection-related mortality that is predominantly related to CMV, adenovirus (Adv), and EBV. Adoptive immunotherapy with peripheral blood-derived virus-specific cytotoxic T lymphocytes...
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