Article

CD62L-selected umbilical cord blood universal CAR T cells

2024-01-20

Abstract excerpt

Umbilical cord blood (UCB) T cells exhibit distinct naïve ontogenetic profiles and may be an attractive source of starting cells for the production of chimeric antigen receptor (CAR) T cells. Pre-selection of UCB-T cells on the basis of CD62L expression was investigated as part of a machine-based manufacturing process, incorporating lentiviral transduction, CRISPR-Cas9 editing, T-cell expansion and depletion of re...

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Literature Corpus work: ab37e871-7afe-5028-a88d-2c71b0eb1d23
DOI: 10.1101/2024.01.18.576145

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