Article
Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits.
Frontiers in immunology - 1 Jan 2023
Sanz Marta, Mann Brendan T, Ryan Paul L, Bosque Alberto, Pennington Daniel J, Hackstein Holger, Soriano-Sarabia Natalia
Abstract excerpt
Under non-pathological conditions, human γδ T cells represent a small fraction of CD3+ T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independent presentation. Major human γδ T cell subsets, Vδ1 and Vδ2, expand in response to microbial infection or malignancy, but possess distinct tissue localization, antigen...
Topics
- Humans
- T-Lymphocyte Subsets
- Receptors, Antigen, T-Cell, gamma-delta
- Intraepithelial Lymphocytes
- Phenotype
- Neoplasms