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Article

HIV-1 Tat Upregulates TREM1 Expression in Human Microglia

16 Jun 2023

Abstract excerpt

Because microglia are a reservoir for HIV and are resistant to the cytopathic effects of HIV infection, they are a roadblock for any HIV cure strategy. We have previously identified that triggering receptor expressed on myeloid cells 1 (TREM1) plays a key role in human macrophage resistance to HIV-mediated cytopathogenesis. In this article, we show that HIV-infected human microglia express increased levels of...

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PMID: 37326481
DOI: 10.4049/jimmunol.2300152

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