Article
HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.
Neuroimmunomodulation - 1 Jan 2000
Mayne M, Bratanich A C, Chen P, Rana F, Nath A, Power C
Abstract excerpt
Activation and infection by HIV-1 of glial cells and infiltrating macrophages are cardinal features of AIDS-related neurological disease. Tumor necrosis factor-alpha (TNF-alpha) is released by these cell types, and increased TNF-alpha mRNA and protein levels are associated with the development an...
Topics
- AIDS Dementia Complex
- Astrocytoma
- Dose-Response Relationship, Immunologic
- Gene Expression Regulation, Viral
- Gene Products, tat
- Genetic Variation
- HIV-1
- Humans
- Jurkat Cells
- Molecular Sequence Data
- NF-kappa B
- RNA, Messenger
- Sequence Homology, Amino Acid
- Tumor Necrosis Factor-alpha
- U937 Cells
- Viral Proteins
- tat Gene Products, Human Immunodeficiency Virus