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Article

HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.

Neuroimmunomodulation - 1 Jan 2000

Mayne M, Bratanich A C, Chen P, Rana F, Nath A, Power C

Abstract excerpt

Activation and infection by HIV-1 of glial cells and infiltrating macrophages are cardinal features of AIDS-related neurological disease. Tumor necrosis factor-alpha (TNF-alpha) is released by these cell types, and increased TNF-alpha mRNA and protein levels are associated with the development and severity of HIV-induced neurological disease. HIV-1 proteins have been implicated in HIV neuropathogenesis including...

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Identifiers

PMID: 9730685
DOI: 10.1159/000026336

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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