HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1

doi:10.1038/srep42028

Article

HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1

9 Feb 2017

Abstract excerpt

Triggering receptor expressed on myeloid cells-1(TREM-1) is a member of the superimmunoglobulin receptor family. We have previously shown that TREM-1 prolongs survival of macrophages treated with lipoolysaccharide through Egr2-Bcl2 signaling. Recent studies suggest a role for TREM-1 in viral immunity. Human immunodeficiency virus-1 (HIV) targets the monocyte/macrophage lineage at varying stages of infection....

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