Article
Novel HLA-DRB1 alleles contribute risk for disease susceptibility in primary biliary cholangitis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Feb 2022
Li Yanni, Liu Xin, Wang Yi, Zhou Yi, Hu Shixian, Yang Hui, Zhong Weilong, Zhao Jingwen, Wang Xiaoyi, Chu Hongyu, Zheng Yanping, Zhang Jie, Zhou Lu, Wang Bangmao
Abstract excerpt
BACKGROUND: Primary biliary cholangitis (PBC) is a complex disease with high heritability. We investigated the association between human leukocyte antigen (HLA)-DRB1 alleles and PBC in families and sporadic cases to evaluate the genetic components of the disease. METHODS: We performed whole exome sequencing in three PBC families. We genotyped HLA-DRB1 and calculated the association between HLA-DRB1 alleles and...
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