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Article

Agmatine-IRF2BP2 interaction induces M2 phenotype of microglia by increasing IRF2-KLF4 signaling.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Jun 2023

Kim Jiwon, Sim A Young, Barua Sumit, Kim Jong Youl, Lee Jong Eun

Abstract excerpt

BACKGROUND: Following central nervous system (CNS) injury, the investigation for neuroinflammation is vital because of its pleiotropic role in both acute injury and long-term recovery. Agmatine (Agm) is well known for its neuroprotective effects and anti-neuroinflammatory properties. However, Agm's mechanism for neuroprotection is still unclear. We screened target proteins that bind to Agm using a protein...

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PMID: 37314519
DOI: 10.1007/s00011-023-01741-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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